Class IA Phosphatidylinositol 3-Kinase p110α Regulates Phagosome Maturation
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چکیده
منابع مشابه
Class IA Phosphatidylinositol 3-Kinase p110α Regulates Phagosome Maturation
Of the various phosphatidylinositol 3- kinases (PI3Ks), only the class III enzyme Vps34 has been shown to regulate phagosome maturation. During studies of phagosome maturation in THP-1 cells deficient in class IA PI3K p110α, we discovered that this PI3K isoform is required for vacuole maturation to progress beyond acquisition of Rab7 leading to delivery of lysosomal markers. Bead phagosomes fro...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2012
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0043668